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| Julia Roberts | Charlotte A. Cavatica | |
| Dakota Fanning | Fern | |
| Steve Buscemi | Templeton | |
| Dominic Scott Kay | Wilbur | |
| John Cleese | Samuel | |
| Oprah Winfrey | Gussy | |
| Cedric The Entertainer | Golly | |
| Kathy Bates | Bitsy | |
| Reba McEntire | Betsy | |
| André Benjamin | Elwyn | |
| Kevin Anderson | Mr. Arable | 
| Director | 
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| Producer | Jordan Kerner Julia Pistor | ||
| Writer | Karey Kirkpatrick Susannah Grant | ||
| Cinematography | Seamus McGarvey | ||
| Musician | Danny Elfman | 
|  | Wilbur the pig is scared of the end of the season, because he knows that come that time, he will end up on the dinner table. He hatches a plan with Charlotte, a spider that lives in his pen, to ensure that this will never happen. | 
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