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| Willem Dafoe | George Deckert | |
| Samuel L. Jackson | Agent Augustus Gibbons | |
| Scott Speedman | Agent Kyle Steel | |
| Peter Strauss | President James Sanford | |
| Nona Gaye | Lola Jackson | |
| Ice Cube | Darius Stone | |
| Michael Roof | Toby Lee Shavers | |
| Xzibit | Zeke | |
| Barry Sigismondi | Bull | |
| Sunny Mabrey | Charlie | |
| John G. Connolly | Lt. Alabama Cobb | |
| Ramon De Ocampo | Agent Meadows | |
| Ned Schmidtke | Gen. Jack Pettibone | 
| Director | 
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| Producer | Rob Cohen Todd Garner | ||
| Writer | Rich Wilkes Simon Kinberg | ||
| Cinematography | David Tattersall | ||
| Musician | Marco Beltrami | 
|  | Ice Cube stars as Darius Stone, a thrill-seeking troublemaker whose criminal record and extreme sports obsession make him the perfect candidate to be the newest XXX agent. He must save the U.S. government from a deadly conspiracy led by five-star general and Secretary of Defense George Deckert (played by Willem Dafoe). | 
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