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| Tobey Maguire | Spider-Man / Peter Parker | |
| Willem Dafoe | Green Goblin / Norman Osborn | |
| Kirsten Dunst | Mary Jane Watson | |
| James Franco | Harry Osborn | |
| Cliff Robertson | Uncle Ben | |
| Gerry Becker | Maximilian Fargas | |
| Jack Betts | Henry Balkan | |
| Rosemary Harris | Aunt May | |
| K.K. Dodds | Simkins | |
| Joe Manganiello | Flash Thompson | |
| Ron Perkins | Dr. Mendell Stromm | |
| J.K. Simmons | J. Jonah Jameson | |
| Stanley Anderson | General Slocum | |
| Bill Nunn | Joseph Robertson | 
| Director | 
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| Producer | Ian Bryce Laura Ziskin | ||
| Writer | Steve Ditko David Koepp | ||
| Cinematography | Don Burgess | ||
| Musician | Danny Elfman Jerry Cantrell | 
|  | After being chomped by a genetically altered spider, shy high schooler Peter Parker is endowed with amazing superpowers. And while he first uses them to win wrestling matches, he'll eventually need them to battle a villain known as the Green Goblin. Peter's abilities allow him to win the girl of his dreams, but family tragedy and a suspicious best friend leave him emotionally drained. | 
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