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| Henry Travers | Clarence | |
| H.B. Warner | Mr. Gower | |
| James Stewart | George Bailey | |
| Frank Albertson | Sam Wainwright | |
| Ward Bond | Bert | |
| Donna Reed | Mary Hatch | |
| Lionel Barrymore | Mr. Potter | |
| Thomas Mitchell | Uncle Billy | |
| Frank Faylen | Ernie | |
| Beulah Bondi | Mrs. Bailey | |
| Gloria Grahame | Violet | |
| Charles Williams | Cousin Eustace | |
| Samuel S. Hinds | Peter Bailey | |
| Todd Karns | Harry Bailey | |
| Mary Treen | Cousin Tilly | 
| Director | 
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| Producer | Frank Capra | ||
| Writer | Frank Capra Jo Swerling | ||
| Cinematography | Joseph F. Biroc | ||
| Musician | Dimitri Tiomkin | 
|  | An angel helps a compassionate but despairingly frustrated businessman by showing what life would had been like if he never existed. | 
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