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| George Clooney | Seth Gecko | |
| Salma Hayek | Santanico Pandemonium | |
| Harvey Keitel | Jacob Fuller | |
| Juliette Lewis | Kate Fuller | |
| Ernest Liu | Scott Fuller | |
| Cheech Marin | Border Guard / Chet Pussy / Carlos | |
| Kelly Preston | Newscaster Kelly Houge | |
| Quentin Tarantino | Richard Gecko | |
| Fred Williamson | Frost | |
| John Hawkes | Pete Bottoms | |
| Brenda Hillhouse | Hostage Gloria | |
| Michael Parks | Texas Ranger Earl McGraw | |
| Tom Savini | Sex Machine | |
| John Saxon | FBI Agent Stanley Chase | |
| Danny Trejo | Razor Charlie | 
| Director | 
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| Producer | Robert Rodriguez Elizabeth Avellan | ||
| Writer | Quentin Tarantino Robert Kurtzman | ||
| Cinematography | Guillermo Navarro | ||
| Musician | Graeme Revell | 
|  | Seth Gecko and his younger brother Richard are on the run after a bloody bank robbery in Texas. They escape across the border into Mexico and will be home-free the next morning, when they pay off the local kingpin. They just have to survive 'from dusk till dawn' at the rendezvous point, which turns out to be a Hell of a strip joint. | 
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